CLINICAL AND LABORATORY FEATURES OF THE COURSE OF CHRONIC VIRAL HEPATITIS B AND C IN CHILDREN OF PODILSKY REGION: POSSIBILITY FOR MODERN MONITORING

Introduction. In modern hepatology, a special place is occupied by chronic viral hepatitis, including B and C, because today they occupy the leading positions due to their high prevalence, possibility of severe complications, also could lead death in both adults children. Specialists should have comprehensive understanding clinical course laboratory diagnosis hepatitis facilitate timely effective management this condition.
 The aim: evaluate features C children determining patterns between parametric indexes characterizing processes liver fibrosis.
 Materials methods. process scientific research, 49 were examined, 29 with diagnosed (group I) 20 almost healthy II). diagnoses CHB CHC confirmed PCR method specific markers detected ELISA. All examined patients underwent anamnesis collection, general examination, calculation CDS, Lok, GUCI, APRI, FIB-4 "Fibrotest" diagnostic indexes. Statistical data analysis was carried out "R-Studio" "Statistica 10.0" software, using methods descriptive statistics, correlation analysis. Significance considered significant at p<0.05. study conducted compliance principles Declaration Helsinki.
 Results. It established that levels ALT, AST, GGT, ALP, indirect bilirubin, international normalized ratio (INR) significantly higher I group. level CDS index group (5,97±0,30), compared II (4,35±0,28) (p<0,001). A similar trend noted Lok GUCI APRI indices (1,02±0,22; 0,73±0,04), (0,27±0,02; 0,23±0,02) (p<0,01).
 Conclusions. Implementation non-invasive into practice for will allow dynamic monitoring fibrogenesis processes.